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Shi-Chuen Miaw Associate Professor

Shi-Chuen Miaw

Education and Experience

  • 1998 Ph.D.  Department of Biological Sciences, University of Maryland Baltimore County, USA
  • 1988 M.S.    Institute of Fisheries Science, National Taiwan University
  • 1986 B.S.     Department of Zoology, National Taiwan University (Now Dept. Life Science)

 

Experience

  • 2011~　　     Associate Professor   Graduate Institute of Immunology, National Taiwan University
  • 2003~2011　Assistant Professor    Graduate Institute of Immunology, National Taiwan University
  • 2002~2003　Postdoctoral Fellow   Harvard University -Harvard Medical School, USA
  • 1998~2002　Postdoctoral Fellow   Harvard School of Public Health, USA

 

The research interests in my laboratory are (1) molecular and cellular regulation in helper T (TH) cell differentiation; (2) regulation of IL-4/10/21 cytokine gene expressions by post-translational modified c-Maf; (3) role of transcription factor c-Maf in iNKT cell differentiation; (4) regulation of CD4 T cell nucleotide metabolism by c-Maf in cancer immunity; (5) regulation of IL-2 cytokine gene by transcription factor Ets-1; (6) regulation of IL-23/IL-17-axis by galectin-3; (7) role of novel chemokine Fam19a4 in inflammation, (8) role of CBP phosphorylation and microbiota in mucosal immunity, and (9) role of Ak4 in the metabolism and inflammation of inflammatory macrophages.

  1. Chin WY, He CY, Chow TW, Yu QY, Lai LC, Miaw SC*. Adenylate kinase 4 Promotes Inflammatory Gene Expression via Hif1a and AMPK in Macrophages. FRONTIERS IN IMMUNOLOGY. 2021 MAR 15; 12: 630318. doi: 10.3389/fimmu.2021.630318 (*Corresponding author).
  2. Li TC, Liu CC, Lee YZ, Hsu YH, Chiang CF, Miaw SC*, Lin WL. Combination Therapy of Pulsed-Wave Ultrasound Hyperthermia and Immunostimulant OK-432 Enhances Systemic Antitumor Immunity for Cancer Treatment. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY. 2020 APR 13; 108(1):140-149. (*Co-corresponding author)
  3. Yu JS, Hamada M, Ohtsuka S, Yoh K, Takahashi S, Miaw SC*. Differentiation of IL-17-Producing Invariant Natural Killer T Cells Requires Expression of the Transcription Factor c-Maf. FRONTIERS IN IMMUNOLOGY. 2017 OCT 27; 8:1399. doi: 10.3389/fimmu.2017.01399. (*Corresponding author)
  4. 4.    Ho IC, Miaw SC. Regulation of IL-4 Expression in Immunity and Diseases. ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY. 2016; 941:31-77.
  5. Liu CC, Lai CY, Yen WF, Lin YH, Chang HH, Tai TS, Lu YJ, Tsao HW, Ho IC, Miaw SC*. Reciprocal regulation of c-Maf tyrosine phosphorylation by Tec and Ptpn22. PLOS ONE. 2015 MAY; 10(5):e0127617. (*Corresponding author)
  6. Tsao HW, Tai TS, Tseng W, Chang HH, Grenningloh R, Miaw SC*, Ho IC. Ets-1 facilitates nuclear entry of NFAT proteins and their recruitment to the IL-2 promoter. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2013 SEP; 110(39):15776-15781. (*Co-corresponding author)
  7. Wu SY, Yu JS, Liu FT, Miaw SC*, Wu-Hsieh BA. Galectin-3 negatively regulates dendritic cell production of IL-23/IL-17-axis cytokines in infection by Histoplasma capsulatum. THE JOURNAL OF IMMUNOLOGY. 2013 APR; 190(7):3427-3437. (*Co-corresponding author)
  8. Lai CY, Lin SY, Wu CK, Yeh LT, Sytwu HK, Miaw SC*. Tyrosine phosphorylation of c-Maf enhances the expression of IL-4 gene. THE JOURNAL OF IMMUNOLOGY. 2012 AUG; 189(4):1545-1550.   (*Corresponding author)
  9. Miaw SC#, Chen JS, Hsieh PC, Liu CY, Chung MH, Chen PC, Chang ML, Chen FL, Kung JT, Wang LF. CD44-deficient mice do not exhibit impairment of epidermal Langerhans cell migration to lymph nodes after epicutaneous sensitization with protein. JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2010 JUN; 130: 2674-2677. (#First author)
  10. Lin BS, Tsai PY, Hsieh WY, Tsao HW, Liu MW, Grenningloh R, Wang LF, Ho IC, Miaw SC*. SUMOylation attenuates c-Maf-dependent IL-4 expression. EUROPEAN JOURNAL OF IMMUNOLOGY. 2010 APR; 40: 1174-1184. (*Corresponding author. This is a cover article)
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