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Chia-Chi Ku Associate Professor

Chia-Chi Ku

Education and Experience

  • 1999  Ph.D.  Immunology, University of Colorado (Health Sciences Center), USA
  • 1992   M.S.   Epidemiology, National Taiwan University
  • 1989   B.S.    Public health, National Taiwan University

Experience

  • 2017.08~                 Associate Professor     Graduate Institute of Immunology, National Taiwan University
  • 2006.8 ~ 2017.07  Assistant Professor      Graduate Institute of Immunology, National Taiwan University
  • 1999 ~ 2006           Postdoctoral fellow      Stanford University

Viral immunity
T cell memory
IL-15 and innate immunity

  1. Yi-Hua Pan, Mei-Ying Liao, Yu-Wen Chien, Tzong-Shiann Ho, Hui-Ying Ko,   Chin-Rur Yang, Shu-Fen Chang, Chia-Yi Yu, Shu-Yu Lin, Pin-Wei Shih, Pei-Yun Shu, Day-Yu Chao, Chao-Ying Pan, Hong-Ming Chen, Guey-Chuen Perng, Chia-Chi Ku*, and Chwan-Chuen King*. Use of seroprevalence to guide dengue vaccination plans for older adults in a dengue non-endemic country. PLOS Neglected Tropical Diseases. 2021. Accepted. (*correspondent author).
  2. Hsin-Fang Tu, Chun-Jung Ko, Ching-Tai Lee, Cheng-Fan Lee, Shao-Wei Lan, Hsin-Hsien Lin, Hsin-Ying Lin, Chia-Chi Ku, Der-Yen Lee, I-Chun Chen, Ya-Hui Chuang, Francisco Del Caño-Ochoa, Santiago Ramón-Maiques, Geen-Dong Chang, Chao-Chi Ho, and Ming-Shyue Lee. Afatinib exerts immunomodulatory effects by targeting the pyrimidine biosynthesis enzyme CAD. Cancer Research, 2021. Accepted.
  3. Lin YJ, Lee TL, and Chia-Chi Ku*.  Development of an economical DNA delivery system by “acufection” and its application to skin research. Journal of Visualized Experiments. 2017 February, doi:10.3791/55206; URL:http://www.jove/video/55206 (*correspondent author).
  4. Jui-Hung Kao, Chaur-Dong Chen, Zheng-Rong Tiger Li, Ta-Chien Chan, Tsung-Hwa Tung, Yin-Hsia Chu, Hau-Yuan Cheng, Jien-Wei Liu, Fuh-Yuan Shih, Pei-Yun Shu, Chien-Chou Lin, Wu-Hsiung Tsai, Chia-Chi Ku*, Chi-Kung Ho*, Chwan-Chuen King*. The Critical Role of Early Dengue Surveillance and Limitations of Clinical Reporting – Implications for Non-Endemic Countries.  PLos One. 2016, AUG;11:e0160230. (* corresponding author)
  5. Chia-Chi Ku*, Yi-Hsuan Chang, Yun Chien, Tsung-Lin Lee. Type I interferon inhibits varicella-zoster virus replication by interfering with the dynamic interaction between Mediator and IE62 within replication compartments. Cell & Bioscience, 2016, MAR; 6:212016. (* corresponding author)
  6. Lee TL, Chang ML, Lin YJ, Tsai MH, Chang YH, Chuang CM, Chien Y, Sosinowski T, Wang CH, Chen YY, Lee CK, Chen JS, Wang LF, Kung* JT and Chia-Chi Ku*.  An alternatively spliced IL-15 isoform modulates abrasion-induced keratinocyte activation, 2015. Journal of Investigative Dermatology, 135: 1329-1337 (* corresponding author)
  7. 7. Yen-Chun Chen, Cheing-Meei Liu, Jiiang-Huei Jeng, and Chia-Chi Ku*, 2014. Association of Pocket Epithelial Cell Proliferation in Periodontitis with TLR9 Expression and Inflammatory Response. Journal of the Formosan Medical Association. Association of Pocket Epithelial Cell Proliferation in Periodontitis with TLR9 Expression and Inflammatory Response. Journal of the Formosan Medical Association. Aug;113:549-556. http://dx.doi.org/10.1016/j.jfma.2012.07.043 (* correspondent author).
  8. Adel M. Nour, Mike Reichelt, Chia-Chi Ku, Min-Yin Ho, Thomas C. Heineman, and Ann M. Arvin, 2011. Varicella-zoster virus infection triggers formation of the NLRP3 inflammasome complex.  J Biol Chem. 2011 May 20;286(20):17921-33. Epub 2011 Mar 8.
  9. Chia-Chi Ku, Xi-Bing Che, Mike Reichelt, Jaya Rajamani, Anne Schaap-Nutt, Ke-Jung Huang, Marvin H. Sommer, Yi-Shun Chen, Yi-Yuan Chen, and Ann M. Arvin, 2011.   Herpes Simplex Virus-1 Induces Expression of a Novel MxA Isoform that Enhances Viral Replication.  Immunology and Cell Biology, 2011 Feb;89(2):173-82. Epub 2010 Jul 6.
  10. Ann M. Arvin, Jennifer Moffat, Marvin Sommer, Stefan Oliver, Xibing Che, Leigh Zerboni and Chia-Chi Ku, 2010.  Varicella-Zoster Virus T cell Tropism and the Pathogenesis of Skin Infection, Current Topics in Microbiology and Immunology, 142: pp.189-209.

  11. Homologous and Heterologous Neutralization Antibody Responses After Immunization With Japanese Encephalitis Vaccine Among Taiwan Children, Journal of Medical Virology(1994)

  12. Characteristics and maintenance of CD8 T-cell clones found in old mice, Mechanisms of Ageing and Development(1997)

  13. CD8+ T-cell clones in old mice, Immunotogicol Reviews(1997)

  14. Control of Homeostasis of CD81 Memory T Cells by Opposing Cytokines, SCIENCE(2000)

  15. The Growth of the Very Large CD81 T Cell Clones in Older Mice Is Controlled by Cytokines1, The Journal of Immunology(2001)

  16. Mutational Analysis of the Repeated Open Reading Frames, ORFs 63 and 70 and ORFs 64 and 69, of Varicella-Zoster Virus, JOURNAL OF VIROLOGY(2001)

  17. Varicella-Zoster Virus Transfer to Skin by T Cells and Modulation of Viral Replication by Epidermal Cell Interferon-a, The Journal of Experimental Medicine(2004)

  18. MINIREVIEW: Varicella-Zoster Virus Pathogenesis and Immunobiology: New Concepts Emerging from Investigations with the SCIDhu Mouse Model, JOURNAL OF VIROLOGY(2005)

  19. Varicella-zoster virus infection of human dorsal root ganglia in vivo, PNAS(2005)

  20. T-Cell Tropism and the Role of ORF66 Protein in Pathogenesis of Varicella-Zoster Virus Infection, JOURNAL OF VIROLOGY(2005)

  21. Endonuclease G: A role for the enzyme in recombination and cellular proliferation, PNAS(2006)

  22. Herpes simplex virus-1 induces expression of a novel MxA isoform that enhances viral replication, Immunology and Cell Biology (2011)

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